RNA binding Energy Funnel on protein surface plotted as rainbow color
Current prediction methods cannot distinguish RNA binding proteins from DNA binding ones
Prediction score is related to minimum distance from a residue to nucleic acid atoms
Nucleic acid binding funnel is similar to protein folding and protein-nucleic acid docking energy funnels
Energy funnels for different proteins are not necessarily the same
To distinguish binding difference for single point mutation is important for binding site prediction programs
RNA/DNA binding site prediction on protein is a well-established field. Many computational prediction web service and programs have been proposed. A fair comparison of all the programs can improve
our understanding of nucleic acid-protein binding mechanism. Currently existing prediction methods differ in:
1) definition of binding sites;
2) datasets used for training and test;
3) stability of the prediction;
4) metrics used in assessment;
5) the ease-of-use.
With the help of results from this database, we get to know :1) the current state of binding site prediction programs; 2) the bottle-neck of the prediction problem; 3) the underlying principle
of nucleic acid-protein binding.
3) prediction result of all the methods on all the datasets;
4) various assessment metrics applied on all the prediction methods on all the datasets.
Find the Results
Besides, registered users can submit the datasets and prediction results of their own methods. Thus, we can better know how all of these new upcoming methods work.
We strongly encourage submission of prediction results. Submit your predictions (Please register before your submission.)